achim kramer lab

:selected publications

2011

Relógio A, Westermark PO, Wallach T, Schellenberg K, Kramer A, Herzel H
Tuning the mammalian circadian clock: robust synergy of two loops.
Plos Comput Biol 7(12):e1002309. (2011 Dec 15) [PubMed Link]

Spörl F, Schellenberg K, Blatt T, Wenck H, Wittern KP, Schrader A, Kramer A
A Circadian Clock in HaCaT Keratinocytes.
J Invest Dermatol. 131(2):338-48. (2010 Oct 21) [PubMed Link]

Teschke M, Wendt S, Kawaguchi S, Kramer A*, Meyer B.
A Circadian Clock in Antarctic Krill: An Endogenous Timing System Governs Metabolic Output Rhythms in the Euphausid Species Euphausia superba.
PLoS One 6:e26090. (2011 Oct 7) [PubMed Link] (*=corresponding author)

Schmutz I, Wendt S, Schnell A, Kramer A, Mansuy IM, Albrecht U.
Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.
PLoS One 6:e21325 (2011 Jun 21) [PubMed Link]

Reischl S, Kramer A.
Kinases and phosphatases in the mammalian circadian clock.
FEBS Lett. 585:1393-9 (2011 Mar 3) [PubMed Link]

2010

Abraham U, Granada AE, Westermark PO, Heine M, Kramer A, Herzel H
Coupling governs entrainment range of circadian clocks.
Mol Syst Biol. 6:438 (2010 Nov 30) [PubMed Link]

Ko HW, Kim EY, Chiu J, Vanselow JT, Kramer A, Edery I
A hierarchical phosphorylation cascade that regulates the timing of PERIOD nuclear entry reveals novel roles for proline-directed kinases and GSK-3beta/SGG in circadian clocks.
J Neurosci. 30(38):12664-75 (2010 Sep 22) [PubMed Link]

2009

Keller M, Mazuch J, Abraham U, Eom GD, Herzog ED, Volk HD, Kramer A*, Maier B
A circadian clock in macrophages controls inflammatory immune responses.
Proc Natl Acad Sci USA. 106(50):21407-12. (2009 Dec 1) [PubMed Link] (*=corresponding author)

Hennig S, Strauss HM, Vanselow K, Yildiz O, Schulze S, Arens J, Kramer A, Wolf E
Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2.
PLoS Biol. 7(4):e94. (2009 Apr 28) [PubMed Link]

Bozek K, Kielbasa SM, Relógio A, Heine M, Dame C, Kramer A, Herzel H
Regulation of clock controlled genes in mammals.
PLoS ONE 4(3):e4882 (2009 Mar 16) [PubMed Link]

Maier B, Wendt S, Vanselow JT, Wallach T, Reischl S, Oehmke S, Schlosser A, Kramer A
A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock.
Genes Dev. 2009, 23:708-718 (2009 Mar 15) [PubMed Link]

2008

Chiu JC, Vanselow JT, Kramer A, Edery I.
The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.
Genes Dev. 22(13):1758-72. (2008 Jul 1) [PubMed Link]

Locke JC, Westermark PO, Kramer A, Herzel H.
Global parameter search reveals design principles of the mammalian circadian clock.
BMC Syst Biol. 2(1):22. (2008 Feb 29) [PubMed Link]

Brown SA, Kunz D, Dumas A, Westermark PO, Vanselow K, Tilmann-Wahnschaffe A, Herzel H, Kramer A
Molecular insights into human daily behavior.
PNAS. 105(5):1602-7. (2008 Feb 5) [PubMed Link]

2007

Vanselow K, Kramer A.
Role of phosphorylation in the mammalian circadian clock.
Cold Spring Harb Symp Quant Biol. 72:167-76. (2007) [PubMed Link]

Bozek K, Kielbasa SM, Kramer A, Herzel H.
Promoter analysis of Mammalian clock controlled genes.
Genome Inform. 18:65-74. (2007) [PubMed Link]

Schlosser A, Vanselow JT, Kramer A
Comprehensive Phosphorylation Site Analysis of Individual Phosphoproteins Applying Scoring Schemes for MS/MS Data.
Anal Chem. 79(19):7439-49. (2007 Oct 1) [Pubmed Link]

Reischl S, Vanselow K, Westermark PO, Thierfelder N, Maier B, Herzel H, Kramer A
ß-TrCP1 mediated degradation of PERIOD2 is essential for circadian dynamics.
J Biol Rhythms. 22(5):375-86. (2007 Oct) [Pubmed Link]

Bernard S, Gonze D, Cajavec B, Herzel H, Kramer A (2007)
Synchronization-Induced Rhythmicity of Circadian Oscillators in the Suprachiasmatic Nucleus.
Plos Comput Biol. 3(4):e68. (2007 Apr 13) [Pubmed Link]

Zhao W-N, Malinin N, Yang F-C, Staknis D, Gekakis N, Maier B, Reischl S, Kramer A, Weitz CJ
CIPC is a mammalian circadian clock protein without invertebrate homologs.
Nature Cell Biol. 9(3):268-75. (2007 Mar) [Pubmed Link]

2006

Vanselow K, Vanselow JT, Westermark PO, Reischl S, Maier B, Korte T, Herrmann A, Herzel H, Schlosser A, Kramer A. (2006).
Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS).
Genes Dev. 20(19):2660-72. (2006 Oct 1) [Pubmed Link]

2005

Schlosser A, Vanselow JT, Kramer A
Mapping of phosphorylation sites by a multi-protease approach with specific phosphopeptide enrichment and NanoLC-MS/MS analysis.
Anal Chem. 77(16):5243-50. (2005 Aug 15) [Pubmed Link]

Gonze D, Bernard S, Waltermann C, Kramer A, Herzel H
Spontaneous synchronization of coupled circadian oscillators.
Biophys J. 89(1):120-9. (2005 Apr 22) [Pubmed Link]

Geier, F., Becker-Weimann, S., Kramer, A. and Herzel, H
Entrainment in a model of the mammalian circadian oscillator.
J Biol Rhythms. 20(1):83-93. (2005 Feb) [Pubmed Link]

Kramer A, Yang FC, Kraves S, Weitz CJ
A screen for secreted factors of the suprachiasmatic nucleus.
Methods Enzymol. 393:645-63. (2005) [Pubmed Link]

2004

Becker-Weimann S, Wolf J, Herzel H, Kramer A
Modeling feedback loops of the mammalian circadian oscillator.
Biophys J. 87(5):3023-34. (2004 Sep 3) [Pubmed Link]

2001

Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ
Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling.
Science 294, 2511-2515. (2001 Dec 21) [Pubmed Link]

Portwich M, Keller S, Strauss HM, Mahrenholz CC, Kretzschmar I, Kramer A, Volkmer R (2007).
A network of coiled-coil associations derived from synthetic GCN4 leucine zipper arrays.
Angewandte Chemie Int Ed. 2007;46(10):1654-7. [Pubmed Link]

Hoffmüller U., Knaute T., Hahn M., Höhne W., Schneider-Mergener J., Kramer A. (2000).
Evolutionary transition pathways for changing peptide ligand specificity and structure.
EMBO J. 19, 4866-4874. [Pubmed Link]

Maier, B., Molinger, M., Cope, A. P., Fugger, L., Schneider-Mergener, J., S�nderstrup, G., Kamradt, T., and Kramer, A. (2000).
Multiple cross-reactive self-ligands for Borrelia burgdorferi-specific HLA-DR4-restricted T cells.
Eur J Immunol. 30, 448-457. [Pubmed Link]

Winkler, K., Kramer, A., Küttner, G., Seifert, M., Scholz, C., Wessner, H. Schneider-Mergener, J. and Höhne, W. (2000).
Changing the antigen binding specificity by single point mutations of an anti-p24 (HIV-1) antibody.
J Immunol. 165, 4506-4514. [Pubmed Link]

Kramer, A. and Schneider-Mergener, J. (1998).
Synthesis and application of peptide libraries bound to continuous cellulose membranes.
Meth Mol Biol. 87, 25-39. [Pubmed Link]

Kramer, A., Keitel, T., Höhne, W. and Schneider-Mergener, J. (1997).
Molecular basis of the binding promiscuity of an anti-p24 (HIV-1) monoclonal antibody.
Cell. 91, 799-809. [Pubmed Link]

Keitel, T., Kramer, A., Wessner, H., Scholz, C., Schneider-Mergener, J. and Höhne, W. (1997).
Crystallographic analysis of of an anti-p24 (HIV-1) monoclonal antibody cross reactivity and polyspecificity.
Cell. 91, 811-820. [Pubmed Link]